Currently coeliac serological testing is not reliable enough to eliminate the need for small bowel biopsy. Recent guidelines from the European Society for Paediatric Gastroenterology and Hepatology and Nutrition (ESPGHAN), have recommended that if the TTG-IgA is >10XULN, and EMA +ve, and HLA DQ2 or 8 +ve, and history is consistent, then a small bowel … Continue reading Is small bowel biopsy still necessary if coeliac serology is highly suggestive?